Bookmark and Share

Funded Clinical Research

Funded clinical research is directed towards participation in multi or single center trials for the management of stroke, subarachnoid hemorrhage, intracerebral and intraventricular hemorrhage, traumatic brain injury, spinal cord injury and focused ultrasound in treatment for essential tremor and Parkinson's disease.

A clinical research manager, two research project coordinators support this research with funding from federal, industry, and private grants.

Jump to:

 


Clinical Research Staff

Charlene Aldrich, RN, MSN  

Charlene Aldrich, RN, MSN - Clinical Research Manager  

  • Masters in Nursing
  • Clinical Research Manager for Neurosurgery Research
  • Coordinats and manages multiple Neurosurgical research studies
  • Qualified in grant proposal writing and billing management
 
Kaitlyn Henry, B.S.  

Kaitlyn Henry, B.S. – Research Project Coordinator 

  • Bachelor of Arts in Neuroscience
  • Coordinates and manages multiple Neurosurgical research studies
 
Allyson Reid, B.A.  

Allyson Reid, B.A. – Research Project Coordinator 

  • Bachelor of Arts in Neuroscience
  • Coordinates and manages multiple Neurosurgical research studies
 

Back to top 

Overview of Neurosurgical Clinical Research

  • Coordinates research protocols from large multicenter studies and Principal Investigator initiated studies
  • Manages multiple grants from the National Institutes of Health (NIH), the Department of Defense (DoD) and Industry Sponsors
  • Directs several current protocols engendered from the laboratory of Dr. Marc Simard M.D., Ph.D., which are now in the clinical phase:
    • Innovative use of Glyburide, a drug used in the treatment of diabetes, for the treatment of traumatic brain injury and ischemic stroke
    • Conduct traumatic, acture and chronic disease studies.
     

Clinical Research Studies for Spinal Cord Injury  

Quick Title  

Expanded Title  

Principal Investigator  

Sponsor  

NACTN 

North American Clinical Trial Network for spinal cord injury (Registry)

Bizhan Aarabi, MD

Christopher and Dana Reeve Foundation

RISCIS 

Multi-center, randomized, placebo-controlled, double-blind trial of efficacy and safety of Riluzole in acute spinal cord injury started within 12 hours of injury

Bizhan Aarabi, MD

AOSpine International; Christopher and Dana Reeve Foundation; Rick Hansen Institute

HuCNS-SC  

A Single-Blind, Randomized, Parallel Arm,
Phase II Proof-of-Concept Study of the Safety and Efficacy
of HuCNS-SC Transplantation in
Cervical Spinal Cord Injury

Bizhan Aarabi, MD

StemCell Inc

 

Clinical Research Studies for Subarachnoid Hemorrhage (SAH) and Stroke  

Quick Title  

Expanded Title  

Principal Investigator  

Sponsor  

CLEAR III 

Clot Lysis: Evaluating accelerated resolution of intraventricular hemorrhage, Phase III

Francois Aldrich, MB, ChB, MMed, FCS

National Institutes of Health (NIH)

i-DEF  

Deferoxamine mesylate in intracerebral hemorrhage - A phase II prospective, multi-center, double-blind, randomized, placebo-controlled, phase II clinical trial

Francois Aldrich, MB, ChB, MMed, FCS

National Institute of Neurological Disorders and Stroke (NINDS)

MISTIE III 

Minimally invasive surgery plus rt-PA for intracranial hemorrhage evacuation

Francois Aldrich, MB, ChB, MMed, FCS

National Institutes of Health (NIH)

 

Clinical Research Study for Movement Disorders 

Quick Title  

Expanded Title  

Principal Investigator  

Sponsor  

ET002  MRgFUS  

A Pivotal Study to Evaluate the Effectiveness and Safety of ExAblate Transcranial MRgFUS Thalamotomy Treatment of Medication Refractory Essential Tremor Subjects

Howard Eisenberg, MD

InSightec

ET002  MRgFUS CA A Pivotal Study to Evaluate the Effectiveness and Safety of ExAblate Transcranial MRgFUS Thalamotomy Treatment of Medication Refractory Essential Tremor Subjects Howard Eisenberg, MD InSightec
PD002 MRgFus  A Phase I Clinical Trial of the Management of the Medically-Refractory Motor Symptoms of Advanced Idiopathic Parkinson’s Disease with Unilateral Lesioning of the Globus Pallidum Using the ExAblate Transcranial System

Howard Eisenberg, MD

Graeme Woodworth, MD

Insightec

FUS Foundation

 

Clinical Research Studies for Ischemic Stroke  

Quick Title  

Expanded Title  

Principal Investigator  

Sponsor  

GAMES  

Glyburide advantage in malignant edema and stroke

Carolyn Cronin, MD

Remedy Pharmaceuticals

SHINE 

Stroke hyperglycemia insulin network effort (SHINE) trial protocol

Marcella Wozniak, MD

National Institute of Neurological Disorders and Stroke (NINDS)

 

Clinical Research Study for Aneurysms  

Quick Title  

Expanded Title  

Principal Investigator  

Sponsor  

Edge 

EG-1962 and nimodipine vs. placebo in aneurysm

Francois Aldrich, MB, ChB, MMed, FCS

Edge Therapeutics, Inc.

Back to top 

Current Clinical & Non-Clinical Research Grants

Bizhan Aarabi, M.D.  

Principal Investigator
NACTN: North American clinical trials network for treatment of spinal cord injury
Sponsor: Christopher and Dana Reeve Foundation
Date: 2004 - present

Principal Investigator
RISCIS: Multicenter, randomized, placebo-controlled, double-blind trial of efficacy and safety of Riluzole in acute spinal cord injury started within 12 hours of injury
Sponsors: AOSpine International, Christopher and Dana Reeve Foundation, and Rick Hansen Institute
Date: 2013 – present


E. Francois Aldrich, M.D.  

Principal Investigator
CLEAR III: Clot Lysis – Evaluating accelerated resolution of intraventricular hemorrhage, phase III
Sponsor: National Institutes of Health
Date: 2004 - present

Principal Investigator
Edge: EG-1962 and nimodipine vs. placebo in aneurysm
Sponsor: Edge Therapeutics, Inc.
Date: 2013 – present

Principal Investigator
DEF: Deferoxamine mesylate in intracerebral hemorrhage, a phase II prospective, multi-center, double-blind, randomized, placebo-controlled, phase II clinical trial
Sponsor: National Institutes of Health, NINDS
Date: 2013 – present

Principal Investigator
MISTIE III: Minimally invasive surgery plus rt-PA for intracranial hemorrhage evacuation
Sponsor: National Institutes of Health
Date: 2005 - present


Howard M. Eisenberg, M.D.  

Principal Investigator for the Clinical Site
SHINE: Stroke hyperglycemia insulin network effort (SHINE) trial protocol
Sponsor: National Institutes of Health, NINDS
Date: 2013 – present

Principal Investigator
Tremor: ExAblate MRI for essential tremor
Sponsor: InSightec
Date: Pending


Vladimir Gerzanich, M.D., Ph.D.  

Principal Investigator
Role of TRP channels in secondary injury after brain edema
Sponsor: National Institutes of Health, NINDS
Date: 2011 - present

Principal Investigator
TRPM4 channel in spinal cord injury
Sponsor: National Institutes of Health, NINDS
Date: 2008 - present

Co-Principal Investigator
Sulfonylurea receptor 1 (SUR1) – A novel therapeutic target in ischemic stroke
Sponsor: National Institutes of Health, NHLBI
Date: 2006 – present


Charles A. Sansur, M.D., M.H.Sc.  

Co-Principal Investigator
RISCIS: Multicenter, randomized, placebo-controlled, double-blind trial of efficacy and safety of Riluzole in acute spinal cord injury started within 12 hours of injury
Sponsors: AOSpine International, Christopher and Dana Reeve Foundation, and Rick Hansen Institute
Date: 2013 – present


J. Marc Simard, M.D., Ph.D.  

Principal Investigator
Pathological role of the SUR1-regulated NC (Ca-ATP) channel in cortex after subarachnoid hemorrhage
Sponsor: National Institutes of Health
Date: 2009 – present

Principal Investigator
Spinal cord injury, progressive hemorrhagic necrosis and the NC (Ca-ATP) channel
Sponsor: National Institutes of Health
Date: 2009 – present

Principal Investigator
Sulfonylurea receptor 1 (SUR1) – A novel therapeutic target in ischemic stroke
Sponsor: National Institutes of Health
Date: 2005 – present

Partnering Principal Investigator
MINIR-II: Minimally invasive neurosurgical intracranial robot
Sponsor: National Institutes of Health, NIBIB
Date: 2012 - present 

Principal Investigator
Role of SUR1 in secondary hemorrhage following traumatic brain injury
Sponsor: Department of Veterans Affairs
Date: 2010 – present

Principal Investigator
Brain injury due to transcranial versus transthoracic blast exposure
Sponsor: Department of Veterans Affairs
Date: 2013 – present

Co-Principal Investigator
Role of TRP channels in secondary injury after brain trauma
Sponsor: National Institutes of Health, NINDS
Date: 2011 - present

Co-Principal Investigator
TRPM4 channel in spinal cord injury
Sponsor: National Institutes of Health, NINDS
Date: 2008 - present

Co-Principal Investigator
CLEAR III: Clot Lysis – Evaluating accelerated resolution of intraventricular hemorrhage, phase III
Sponsor: National Institutes of Health
Date: 2004 - present

Co-Principal Investigator
MISTIE III: Minimally invasive surgery plus rt-PA for intracranial hemorrhage evacuation
Sponsor: National Institutes of Health
Date: 2005 - present

Back to top