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Spinal Cord Injury

We have demonstrated extensively that SUR1/TRPM4 channels are upregulated following spinal cord injury (SCI) in rodents. Importantly, we have shown that pathological opening of the SUR1/TRPM4 channel mediates progressive hemorrhagic necrosis following SCI. Gene suppression of SUR1 blocks expression of functional TRPM4 channels and improves outcome in a spinal cord injury while eliminating secondary hemorrhage. When the channels are blocked by low-dose glibenclamide, it reduces lesion size and hemorrhage while improving neurobehavioral function.

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