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Subarachnoid Hemorrage

We have several ongoing projects in the study subarachnoid hemorrhage (SAH).

Using a modified endovascular filament puncture model of SAH devoid of ischemic injury, we have shown that glibenclamide exerts salutatory anti-inflammatory effects, likely unrelated to blockade of the SUR1/TRPM4 channel.

We have since identified a potent inflammatory mediator that binds to glibenclamide in-vitro, and further investigations are underway.

Additionally, we published an extensive review of the potential use of unfractionated heparin in the context of SAH.

Using a novel stereotactic-guided injection model of SAH and have recently shown that heparin indeed significantly reduces multiple measures of neuroinflammation and cell apoptosis.

Further experiments are planned to compare glibenclamide-treated cohorts to heparin-treated cohorts, along with long-term complex neurobehavioral analysis.

Relevant Publications

 



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