Translational Neuroengineering and Neuroscience
Dr. Jia's research interests include brain monitoring and therapeutic hypothermia, peripheral nerve injury and regeneration, stem cell therapy, biomaterials development for peripheral nerve regeneration.
- Brain Monitoring and Therapeutic Hypothermia The current research focuses on the development of novel translational tools for uncovering mechanisms of brain injury after cardiac arrest, monitoring and tracking the neurological injuries, and guiding treatments like therapeutic hypothermia. The goal is to develop quantitative EEG based neuro-electrical markers of coma and arousal after cardiac arrest, and modulate therapeutic hypothermia by quantitative electrophysiological markers toward improved functional outcome. This project seeks to explore the impact of therapeutic hypothermia on spatio-temporal pattern of glucose utilization measured by small animal positron emission tomography (PET) imaging, and electrophysiological recovery after cardiac arrest.
- Peripheral Nerve Injury This proposal will investigate the effect of neural crest stem cells therapy delivered by 3D printing of bifurcated multi-gradient nerve scaffold in a peripheral nerve defect repair animal model via histopathological, electrophysiological and functional outcome measurements. This project is supported by Maryland Stem Cell Research Fund discovery award.